CASE3: ELEKTRON Stimulation device for preclinical research of de novo cellular antigens

Zenso acted as the engineering expert in a multidisciplinary biotech research project. The project aimed for the discovery of novel antigens by applying extracellular forces.  This experimental bottom-up research required a highly flexible and modular stimulation device for in-vitro and in-vivo purposes. The instrument should allow the cellular specialist to emulate and validate the pre-defined electrical and electro-magnetic protocols for antigen expression.

As a preclinical test instrument, the device should comply with stringent criteria to be employable for high demanding pre-clinical protocols. The key criterion repeatability urged Zenso for an extremely stable and reliable electronics design guaranteeing univocally the same output of the programmed electric function throughout the multiple experiments. The complex load as in in-vivo experiments added supplementary design complexity to this repeatability criterion. Electrical models poorly characterize the complexity of tissue further complicating the electric simulations necessary for design purposes. Pre-clinical testing also demands guaranteed traceability of all test conditions. Therefor the software application, next to being user friendly, had to provide one-to-one correlated logging with the executed experiments. Finally sensitivity testing formed an important research criterion imposing a highly granular configuration while providing the scientists with all necessary logging of the electric settings and corresponding functions as delivered to the cellular matrix whether in suspension or in tissue.

Zenso completed successfully the role of electronic design, software development and final assembly of the stimulation device. More they acted as a true partner in the project providing support and device adjustments whenever required in the different project phases. Ultimately attending experiments in the level I and II microbiological labs.